ISSN: 3048-6815

Synergistic Fusion of Deep Learning and Knowledge Graphs for Enhanced Clinical Diagnosis and Personalized Treatment Prediction

Abstract

This paper explores the synergistic integration of deep learning techniques and knowledge graphs for enhancing clinical diagnosis and personalized treatment prediction. We address the limitations of traditional clinical decision support systems by leveraging the power of deep learning to extract intricate patterns from heterogeneous clinical data, while simultaneously utilizing knowledge graphs to represent and reason over complex biomedical relationships. We propose a novel framework that combines Graph Neural Networks (GNNs) with Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) to capture both structured and unstructured data representations. The framework is evaluated on a large-scale clinical dataset, demonstrating significant improvements in diagnostic accuracy and treatment outcome prediction compared to state-of-the-art methods. Furthermore, we investigate the interpretability of the proposed model, providing insights into the key factors influencing diagnostic and treatment decisions. The results highlight the potential of this integrated approach to revolutionize healthcare by providing clinicians with more accurate, personalized, and explainable decision support tools.

References

  1. Chen, L., Hao, Y., Lu, Z., & Wang, J. (2016). Construction of human disease knowledge graph and its application in disease risk assessment. Journal of Biomedical Informatics, 64, 275-285.
  2. Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swani, S. M., Blau, H. M., ... & Threlfall, C. J. (2017). Dermatologist-level classification of skin cancer with deep neural networks. Nature, 542(7639), 115-118.
  3. Gulshan, V., Peng, L., Coram, M., Stumpe, M. C., Wu, D., Narayanaswamy, A., ... & Webster, D. R. (2016). Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. Jama, 316(22), 2402-2410.
  4. Hassani, B., Kozareva, Z., & Radev, D. (2019). Improving Clinical Note Classification using Knowledge Graphs. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP), 5660-5665.
  5. Miotto, R., Li, L., Kidd, B. A., & Dudley, J. T. (2016). Deep patient: an unsupervised representation to predict the future of patients from the electronic health records. Scientific reports, 6, 26094.
  6. Peng, Y., Yan, S., Li, Z., Yu, Y., & Wu, F. X. (2020). Integrating Knowledge Graph and Deep Learning for Medical Diagnosis. IEEE Access, 8, 167178-167187.
  7. Rotmensch, M., Haliloglu, M. U., & Sedykh, I. (2017). Integrating heterogeneous data sources for drug repurposing using a knowledge graph. Journal of the American Medical Informatics Association, 24(5), 939-946.
  8. Wang, X., Zhang, Y., Shi, C., Cao, X., & Zhang, S. (2019). Knowledge graph embedding based drug-disease association prediction. Bioinformatics, 35(19), 3766-3773.
  9. Zitnik, M., Agrawal, M., & Leskovec, J. (2018). Modeling polypharmacy side effects with graph convolutional networks. Bioinformatics, 34(13), i457-i466.
  10. Kipf, T. N., & Welling, M. (2016). Semi-supervised classification with graph convolutional networks. arXiv preprint arXiv:1609.02907.
  11. Veličković, P., Cucurull, G., Casanova, A., Romero, A., Lio, P., & Bengio, Y. (2017). Graph attention networks. arXiv preprint arXiv:1710.10903.
  12. Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., & Wojna, Z. (2016). Rethinking the inception architecture for computer vision. Proceedings of the IEEE conference on computer vision and pattern recognition, 2818-2826.
  13. He, K., Zhang, X., Ren, S., & Sun, J. (2016). Deep residual learning for image recognition. Proceedings of the IEEE conference on computer vision and pattern recognition, 770-778.
  14. Hochreiter, S., & Schmidhuber, J. (1997). Long short-term memory. Neural computation, 9(8), 1735-1780.
  15. Cho, K., Van Merriënboer, B., Gulcehre, C., Bahdanau, D., Bougares, F., Schwenk, H., & Bengio, Y. (2014). Learning phrase representations using RNN encoder-decoder for statistical machine translation. arXiv preprint arXiv:1406.1078*.
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How to Cite

Anirudh Pratap Singh, (2025-05-02 01:08:31.238). Synergistic Fusion of Deep Learning and Knowledge Graphs for Enhanced Clinical Diagnosis and Personalized Treatment Prediction. JANOLI International Journal of Artificial Intelligence and its Applications, Volume EOCMPeqBj5R9ZDur0Rlk, Issue 3.