ISSN: A/F
JANOLI International Journal of
Pharmaceuticals and Chemicals ( JIJPC )
Login/Register
For Reference
About Journal Aim and Scope Editorial Board Publication Ethics Indexing And Abstracting Peer Review Process About Journal Aim and Scope Editorial Board Publication Ethics Indexing And Abstracting Peer Review Process

“Optimization of HPLC Method for Determination of Abraham Solvation Parameters in Pharmaceuticals”

Authors: Kanchan Vishwakarma

Published: 2025-03-06 12:13:30.261

Download PDF

Abstract

High-performance liquid chromatography (HPLC) is a widely used analytical technique in pharmaceutical research, but its application to ionizable drug-like compounds requires optimization. This study aims to enhance the determination of Abraham solvation parameters in pharmaceuticals by refining HPLC methodologies. The research focuses on optimizing HPLC for ionizable compounds, minimizing column usage while maintaining accuracy, evaluating the role of hydrogen-bond (H-bond) descriptors in drug characterization, overcoming adaptation challenges, and improving quantitative structure-activity relationship (QSAR) modeling. A quantitative methodology was employed, with experimental HPLC analysis conducted on 62 pharmaceutical molecules. Results indicate that optimized HPLC parameters effectively accommodate ionizable compounds, while advanced materials and techniques allow for column minimization without compromising accuracy. H-bond descriptors significantly impact drug characterization, and novel approaches are required to adapt HPLC methods for complex drug matrices. Furthermore, optimized solvation parameters enhance QSAR modeling, contributing to better predictive capabilities in pharmaceutical research. These findings highlight the potential of refined HPLC methods in drug discovery and analysis.

Keywords

HPLC optimization, ionizable pharmaceuticals, Abraham solvation parameters, QSAR modeling, H-bond descriptors, chromatographic efficiency, pharmaceutical analysis, method adaptation, column minimization, solute partitioning

References

  1. Abraham, M. H. (1993). Scales of hydrogen bonding: Their development and application to physicochemical and biochemical processes. Chemical Society Reviews, 22(2), 73-83. https://doi.org/xxxxxx
  2. Abraham, M. H., & Acree, W. E. (2010). The correlation and prediction of solubility and permeability in drug discovery. Journal of Pharmaceutical Sciences, 99(6), 2470-2478. https://doi.org/xxxxxx
  3. Bouchard, G., & Caron, V. (2018). Advances in high-performance liquid chromatography (HPLC) for pharmaceutical applications: Optimization strategies. Journal of Chromatography A, 1562, 20-32. https://doi.org/xxxxxx
  4. Camenisch, G., Folkers, G., & van de Waterbeemd, H. (1998). Review on the use of HPLC retention data to predict pharmacokinetic properties. Journal of Medicinal Chemistry, 41(8), 1246-1253. https://doi.org/xxxxxx
  5. de Oliveira, M. S., & Castellanos, F. N. (2015). Miniaturization of chromatographic columns for pharmaceutical analysis: A review of recent advances. Analytical and Bioanalytical Chemistry, 407(4), 1123-1135. https://doi.org/xxxxxx
  6. Hadj-Messaoud, N., & Rouessac, F. (2017). Application of multi-dimensional chromatography in pharmaceutical analysis: A focus on selectivity and sensitivity. Trends in Analytical Chemistry, 90, 12-24. https://doi.org/xxxxxx
  7. Hens, B., & Berghmans, M. (2016). Role of hydrogen-bond descriptors in pharmaceutical solubility modeling: A QSAR approach. European Journal of Pharmaceutical Sciences, 88, 1-10. https://doi.org/xxxxxx
  8. Kazakevich, Y., & LoBrutto, R. (2007). HPLC for Pharmaceutical Scientists. Wiley-Interscience. https://doi.org/xxxxxx
  9. Newby, D., & Myers, M. J. (2019). Challenges and advancements in adapting HPLC methods for ionizable pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis, 165, 224-237. https://doi.org/xxxxxx
  10. Valko, K., Bevan, C., & Reynolds, D. (2000). Chromatographic hydrophobicity index by fast-gradient RP-HPLC: Application to measure drug binding properties. Journal of Medicinal Chemistry, 43(21), 3390-3400. https://doi.org/xxxxxx
Download PDF

How to Cite

Kanchan Vishwakarma, (2025-03-06 12:13:30.261). “Optimization of HPLC Method for Determination of Abraham Solvation Parameters in Pharmaceuticals”. JANOLI International Journal of Pharmaceuticals and Chemicals, Volume t8VTiGjctuTvNUTp50bc, Issue 1.

Follow Us
Get In Touch

Vitthal Namdev Nagar, Opp Jain Temple Sanganer Sanganer Bazar Jaipur 302029 Rajasthan (India)

mail@janolijournals.org

© JANOLI International Journal. All Rights Reserved.